abstract：:A recent genome-wide association study revealed that there is an association between serum uric acid (SUA) levels and rs2544390, a common variant in low-density lipoprotein-related protein 2 (LRP2/Megalin) gene. Two other variants of LRP2, rs2229268 and rs3755166, are also found to have associations with dyslipidemia ...

journal_title：Rheumatology international

authors： Nakayama A,Matsuo H,Shimizu T,Takada Y,Nakamura T,Shimizu S,Chiba T,Sakiyama M,Naito M,Morita E,Ichida K,Shinomiya N

更新日期：2014-04-01 00:00:00

abstract：:The aim of this study is to investigate whether eutectic mixture of local anesthetics (EMLA) cream phonophoresis superior to conventional US over the trigger points (TPs) in terms of improvements of pain, range of motion and disability in myofascial pain syndrome (MPS). Fifty patients (42 female, 8 male) diagnosed wit...

journal_title：Rheumatology international

authors： Ustun N,Arslan F,Mansuroglu A,Inanoglu D,Yagız AE,Guler H,Turhanoglu AD

更新日期：2014-04-01 00:00:00

abstract：:Autophagosomes are formed during autophagy, which is activated by hypoxia and starvation. Autophagy is important for mast cell degranulation. We hypothesized that autophagy is a key feature in the pathogenesis of systemic sclerosis (SSc). We examined SSc clinical features and mast cell density across the presence and ...

journal_title：Rheumatology international

authors： Frech T,De Domenico I,Murtaugh MA,Revelo MP,Li DY,Sawitzke AD,Drakos S

更新日期：2014-03-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a severe complex rheumatic disease, but good estimate of its prevalence and risk factors is lacking in China. The aim of the study was to explore the prevalence of SLE and risk factors in rural areas of Anhui Province of China. Eleven counties were randomly selected in Anhui Provi...

journal_title：Rheumatology international

authors： Zou YF,Feng CC,Zhu JM,Tao JH,Chen GM,Ye QL,Cen H,Leng RX,Pan FM,Pan HF,Li R,Fan YG,Wang B,Li XP,Zhang FY,Ye DQ

更新日期：2014-03-01 00:00:00

abstract：:The aim was to study the association of smoking with the activity and severity of systemic lupus erythematosus (SLE) and the production of antibodies to dsDNA. The study included 223 SLE patients attending the outpatient clinics at Helsinki University Central Hospital. The history of smoking was obtained by personal i...

journal_title：Rheumatology international

authors： Ekblom-Kullberg S,Kautiainen H,Alha P,Leirisalo-Repo M,Miettinen A,Julkunen H

更新日期：2014-03-01 00:00:00

abstract：:Statistical analysis plays a critical role in data interpretation in all fields and particularly so for clinical data where important treatment decisions are made. We provide here an in-depth and illustrative analysis to examine patterns and radiographic scores in an early disease rheumatoid arthritis cohort over a 3-...

journal_title：Rheumatology international

authors： Park GS,Wong WK,Khanna D,Gold RH,Paulus HE

更新日期：2014-02-01 00:00:00

abstract：:Systemic immune defects might reflect severely dysregulated control of chronic inflammation related to disease progression. Th17/Treg cell imbalance has been demonstrated to be involved in rheumatoid arthritis (RA) pathogenesis. Despite controversial results, a growing anti-inflammatory role in this process has been r...

journal_title：Rheumatology international

authors： Kosmaczewska A,Swierkot J,Ciszak L,Szteblich A,Chrobak A,Karabon L,Partyka A,Szechinski J,Wiland P,Frydecka I

更新日期：2014-02-01 00:00:00

abstract：:The results from previous studies on association of IL-6 -174 G/C and -572 G/C polymorphisms with the risk of systemic lupus erythematosus (SLE) remained inconsistent. Therefore, a meta-analysis was performed to assess the association between these two polymorphisms and SLE susceptibility. A literature-based search wa...

journal_title：Rheumatology international

authors： Yang Z,Liang Y,Qin B,Zhong R

更新日期：2014-02-01 00:00:00

abstract：:The aim of this study was to investigate the percentage of regulatory T cells and the correlation with clinical activity in Behçet's disease. Forty Behçet's disease (BD) patients, 18 males and 22 females, were included in the study. The patients were diagnosed according to the published BD criteria. Twenty age- and se...

journal_title：Rheumatology international

authors： Gündüz E,Teke HU,Bilge NS,Cansu DU,Bal C,Korkmaz C,Gülbaş Z

更新日期：2013-12-01 00:00:00

abstract：:We have investigated the prevalence of dry mouth among patients with autoimmune diseases other than Sjögren's syndrome. One hundred and forty-four patients, excluding patients with primary Sjögren's syndrome, were enrolled in this study. The volume of saliva secreted was measured with the screening technique for estim...

journal_title：Rheumatology international

authors： Maeshima E,Furukawa K,Maeshima S,Koshiba H,Sakamoto W

更新日期：2013-12-01 00:00:00

abstract：:Histoplasmosis is an important cause of morbidity in endemic areas of the USA. Infection is often asymptomatic but can cause a broad spectrum of pathology. Less commonly, histoplasmosis can present with a wide-range of rheumatologic manifestations. The aim of this review is to provide a synopsis of the rheumatologic m...

journal_title：Rheumatology international

authors： Sizemore TC

更新日期：2013-12-01 00:00:00

abstract：:Methotrexate (MTX) is commonly employed as the initial DMARD used for the treatment of rheumatoid arthritis (RA). We aimed to contribute to the safety profile of MTX by assessing its cumulative effect on renal filtration. A total of 52 RA adult female patients with normal baseline serum creatinine and GFR at the initi...

journal_title：Rheumatology international

authors： Amin A,Effat D,Goher N,Ramadan B

更新日期：2013-12-01 00:00:00

abstract：:Several molecular epidemiological studies have been conducted in recent years to evaluate a possible association between the interferon regulatory factor 5 (IRF5) rs2004640 polymorphism and rheumatoid arthritis risk in diverse populations. However, the results remain conflicting rather than conclusive. Our aim was to ...

journal_title：Rheumatology international

authors： Jia X,Hu M,Lin Q,Ren H

更新日期：2013-11-01 00:00:00

abstract：:Autoantibodies have been detected in systemic sclerosis patients, and typical clinical features regarding organ involvement by each autoantibody have been reported. To reveal differences in exercise intolerance in patients with either anti-topoisomerase-I or anti-centromere antibodies, 53 systemic sclerosis patients w...

journal_title：Rheumatology international

authors： Someya F,Mugii N,Yahata T,Nakagawa T

更新日期：2013-11-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic and complex autoimmune disease characterized by the production of autoantibodies against a spectrum of nuclear antigens. RANTES and its receptor CCR5 have been associated with the pathogenesis of SLE. The objective of this study is to analyze autoantibodies (DNA/RNA), al...

journal_title：Rheumatology international

authors： Bidyalaxmi Devi L,Bhatnagar A,Wanchu A,Sharma A

更新日期：2013-11-01 00:00:00

abstract：:Osteoarthritis (OA) has a strong genetic component, and experimental evidence suggests the involvement of the Wnt pathway in its pathogenesis. Hence, we explored the association of common single nucleotide polymorphisms (SNPs) related to the Wnt pathway with hip and knee OA. Seventy-eight SNPs were analyzed in 606 pat...

journal_title：Rheumatology international

authors： García-Ibarbia C,Pérez-Castrillón JL,Ortiz F,Velasco J,Zarrabeitia MT,Sumillera M,Riancho JA

更新日期：2013-11-01 00:00:00

abstract：:In recent years, scientific efforts on the topic "gout" have focused on pathogenetic aspects. This has opened new strategies of anti-inflammatory therapy and has improved urate-lowering therapy. So far, a scientometric analysis of the topic "gout" has not been generated despite an increased need for it in times of mod...

journal_title：Rheumatology international

authors： Gerber A,Groneberg DA,Klingelhöfer D,Bundschuh M

更新日期：2013-11-01 00:00:00

abstract：:Evidence is limited on the association between hyperuricaemia and mortality in children and adolescents. This study was to investigate this association in the paediatric population. The study included children and adolescents who had undergone serum uric acid (SUA) measurement at the Chang Gung Memorial Hospital betwe...

journal_title：Rheumatology international

authors： Hsia SH,Chou IJ,Kuo CF,See LC,Huang JL,Yu KH,Luo SF,Wu CT,Lin KL,Wang HS

更新日期：2013-11-01 00:00:00

abstract：:Meigs' syndrome represents a triad of pleural effusion, ascites, and an ovarian tumor, usually benign, occurring together. We describe here a case of Meigs' syndrome in a patient with systemic sclerosis, the first such report to our knowledge, in systemic sclerosis. A 53-year-old woman with systemic sclerosis presente...

journal_title：Rheumatology international

authors： Su F,Cummings KW,Krigman H,Ranganathan P

更新日期：2013-10-01 00:00:00

abstract：:The objective of this study was to translate and evaluate the psychometric properties of the Thai version of the Rheumatoid Arthritis Disease Activity Index (RADAI) in patients with rheumatoid arthritis (RA). We translated and modified the original RADAI into the Thai version. A total of 116 Thai patients with RA were...

journal_title：Rheumatology international

authors： Katchamart W,Ussavasodhi P,Chiowchanwesawakit P,Chanapai W

更新日期：2013-10-01 00:00:00

abstract：:Both self-reported and physical performance tests are used as outcome measures in knee osteoarthritis (OA). The aim of this study is to investigate the relationship between Knee Injury and Osteoarthritis Outcome Score (KOOS) and Timed Up and Go (TUG) test in the patients with symptomatic knee OA. Eighty-nine patients ...

journal_title：Rheumatology international

authors： Sabirli F,Paker N,Bugdayci D

更新日期：2013-10-01 00:00:00

abstract：:Sphingolipids are components of the plasma membrane whose metabolic manipulation is of interest as a potential therapeutic approach in a number of diseases. Sphingosine kinase 1 (SphK1), the major kinase that phosphorylates sphingosine to sphingosine-1-phosphate (S1P), was previously shown by our group and others to m...

journal_title：Rheumatology international

authors： Baker DA,Eudaly J,Smith CD,Obeid LM,Gilkeson GS

更新日期：2013-10-01 00:00:00

abstract：:Fibromyalgia (FM) is the most common chronic pain syndrome encountered in medical practice, affecting females more than males, and the estimated prevalence of FM in Egypt is 1.3 %. The aim was to translate and adapt the Fibromyalgia Impact Questionnaire (FIQ) into Arabic and assess reliability and validity. The Arabic...

journal_title：Rheumatology international

authors： El-Naby MA,Hefny MA,Fahim AE,Awadalla MA

更新日期：2013-10-01 00:00:00

abstract：:To compare the effects of treatment with punctal plugs versus artificial tears on visual function for primary Sjögren's syndrome with dry eye. Forty-two eyes of 42 patients with primary Sjögren's syndrome were enrolled and were allocated randomly into artificial tears (AT) group and punctal plugs (PP) group. Ocular Su...

journal_title：Rheumatology international

authors： Qiu W,Liu Z,Ao M,Li X,Wang W

更新日期：2013-10-01 00:00:00

abstract：:We report a case of visceral leishmaniasis in a patient from northern Norway with psoriatic arthritis treated with a combination of etanercept and methotrexate. The patient resided extensively in southern Spain, a zone endemic for leishmania. ...

journal_title：Rheumatology international

authors： Besada E,Njålla RJ,Nossent JC

更新日期：2013-10-01 00:00:00

abstract：:In chronic diseases such as rheumatoid arthritis and osteoarthritis, the progression of the disease is characterized by stress oxidative, inflammation, and elevated levels of cholesterol. In mevalonate kinase deficiency, an auto-inflammatory disease, the correlation between inflammation and cholesterol levels is oppos...

journal_title：Rheumatology international

authors： Girardelli M,Bianco AM,Marcuzzi A,Crovella S

更新日期：2013-09-01 00:00:00

abstract：:Folate supplementation is widely accepted and utilized for the prevention of adverse events in juvenile idiopathic arthritis (JIA) patients who are treated with methotrexate. Despite the widespread use of folate supplementation, there is a lack of convincing evidence to support the role of folate in the enhancement of...

journal_title：Rheumatology international

authors： Amarilyo G,Rullo OJ,McCurdy DK,Woo JM,Furst DE

更新日期：2013-09-01 00:00:00

abstract：:To compare oxidative stress (OS) biomarkers and antioxidant capacity of plasma (ACP) between dcSSc (diffuse cutaneous systemic sclerosis) and healthy Mexicans and their possible relationship with autoantibodies, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and uric acid (UA). We included 28 dcSSc an...

journal_title：Rheumatology international

authors： Cruz-Domínguez MP,Montes-Cortes DH,Olivares-Corichi IM,Vera-Lastra O,Medina G,Jara LJ

更新日期：2013-09-01 00:00:00

abstract：:Bisphosphonates such as alendronate, risedronate and zoledronate have revolutionised the treatment for osteoporosis and Paget's disease. These drugs reduce fracture risk and probably mortality in patients with osteoporosis. However, they have a long in vivo half-life following cessation and may be associated with dela...

journal_title：Rheumatology international

authors： Wong PK,Borromeo GL,Wark JD

更新日期：2013-09-01 00:00:00

abstract：:To investigate whether the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5'-AMP and then observe whether hy...

journal_title：Rheumatology international

authors： Miao Z,Guo W,Lu S,Lv W,Li C,Wang Y,Zhao S,Yan S,Tao Z,Wang Y

更新日期：2013-08-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a pleotrophic cytokine that is involved in the pathogenesis of diverse inflammatory rheumatic diseases. The aims of this study were to compare serum IL-15 levels and expression of its receptor (IL-15Rα) in Behçet's disease (BD) with those in other rheumatic diseases and to identify the relati...

journal_title：Rheumatology international

authors： Choe JY,Lee H,Kim SG,Kim MJ,Park SH,Kim SK

更新日期：2013-08-01 00:00:00

abstract：:To determine the forms and characteristics of rheumatic diseases whose initial presentation mimics septic arthritis. Retrospective study of 398 patients hospitalized between 1979 and 2005 for arthritis diagnosed and treated as septic. In 10 cases, initial presentation of a rheumatic disease was highly suggestive of se...

journal_title：Rheumatology international

authors： Eberst-Ledoux J,Tournadre A,Makarawiez C,Le Quang C,Soubrier M,Dubost JJ

更新日期：2013-08-01 00:00:00

abstract：:There are numerous causes of pulmonary cavitary lesions as infection (bacterial, parasitic and invasive fungal), Wegener granulomatosis (WG) and other vasculitis, sarcoidosis, malignancy, septic thromboembolism, airways disease (cystic bronchiectasis and bullae), pneumatoceles and traumatic parenchymal laceration. Her...

journal_title：Rheumatology international

authors： Işik M,Çinar E,Cemal Kizilarslanoğlu M,Özbek E,Etgül S,Kiraz S

更新日期：2013-08-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily involving the spine and sacroiliac joint and rarely the kidneys. This study aimed to define the clinical and histological features and biology of renal disease in AS. We reviewed the medical records of 681 patients diagnosed with AS from November ...

journal_title：Rheumatology international

authors： Lee SH,Lee EJ,Chung SW,Song R,Moon JY,Lee SH,Lim SJ,Lee YA,Hong SJ,Yang HI

更新日期：2013-07-01 00:00:00

abstract：:We report a 53-year-old Turkish female presented with progressive weakness and mild dyspnea. Laboratory results demonstrated severe hypokalemia with hyperchloremic metabolic acidosis. The urinary anion gap was positive in the presence of acidemia, thus she was diagnosed with hypokalemic paralysis from a severe distal ...

journal_title：Rheumatology international

authors： Yılmaz H,Kaya M,Özbek M,ÜUreten K,Safa Yıldırım İ

更新日期：2013-07-01 00:00:00

abstract：:The effect of knee OA on kinetic and kinematic parameters during walking and standing is still controversial. Stability and energy consumption have not been well investigated in patients with OA. This research investigated the parameters distinguishing between the healthy subjects and patients with OA performance. It ...

journal_title：Rheumatology international

authors： Esrafilian A,Karimi MT,Amiri P,Fatoye F

更新日期：2013-07-01 00:00:00

abstract：:Patients with chronic thromboembolic pulmonary hypertension (CTEPH) have poor prognosis, and pulmonary endarterectomy (PEA) is considered the treatment of choice for this condition. We report a case and review the literature of successful PEA for CTEPH due to antiphospholipid syndrome associated with systemic lupus er...

journal_title：Rheumatology international

authors： Kuzenko A,Sciascia S,Silvestro E,Badiu I,Morsolini M,Rovere ME,Bertero MT

更新日期：2013-07-01 00:00:00

abstract：:Resveratrol (trans-3,4'-trihydroxystilbene), a natural phytoalexin, possesses anti-inflammatory, anti-proliferative, and immunomodulatory properties and has the potential for treating inflammatory disorders. The present study was designed to investigate the effects of resveratrol on TNF-α-induced inflammatory cytokine...

journal_title：Rheumatology international

authors： Tian J,Chen JW,Gao JS,Li L,Xie X

更新日期：2013-07-01 00:00:00

abstract：:We evaluated the frequency of secondary amyloidosis, associated clinical features, and outcomes in ankylosing spondylitis (AS) patients diagnosed in the last decade. The medical records of AS patients diagnosed at single academic medical center were reviewed for clinical evidence of amyloidosis. During routine follow-...

journal_title：Rheumatology international

authors： Dönmez S,Pamuk ÖN,Pamuk GE,Aydoğdu E,Inman R

更新日期：2013-07-01 00:00:00

abstract：:The fibromyalgia syndrome (FMS) is a chronic, widespread pain disorder of unknown etiology. It has been suggest that familial component, environmental factors, endocrine and neurotransmitter alterations, and psychological factors may contribute to the development of FMS. The role of melatonin in FMS is unclear. Some s...

journal_title：Rheumatology international

authors： Senel K,Baygutalp F,Baykal T,Erdal A,Ugur M

更新日期：2013-06-01 00:00:00